{"id":3315,"date":"2026-04-01T05:00:05","date_gmt":"2026-04-01T05:00:05","guid":{"rendered":"https:\/\/climatesmartagrifood.ca\/?p=3315"},"modified":"2026-03-06T21:37:36","modified_gmt":"2026-03-06T21:37:36","slug":"3d-model-by-omics4cmeat","status":"publish","type":"post","link":"https:\/\/climatesmartagrifood.ca\/fr\/3d-model-by-omics4cmeat\/","title":{"rendered":"[Research Roundup] Closing the Gap Between 3D Models and Real Tissues by Omics4CMeat"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3315\" class=\"elementor elementor-3315\" data-elementor-post-type=\"post\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-425a9944 e-flex e-con-boxed e-con e-parent\" data-id=\"425a9944\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6a67f9ef elementor-widget elementor-widget-text-editor\" data-id=\"6a67f9ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW125215560 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW125215560 BCX0\">This study by Team <strong>Omics4CMeat<\/strong> focuses on creating a more realistic lab model (&#8220;in vitro model&#8221;) <\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">for forming<\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">\u00a03D\u00a0<\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">tubular tissue barriers that support fluid flow<\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">.\u00a0<\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">Closely mimicking the behavior of real tissues, this simple yet scalable method holds strong potential for studying diseases<\/span><span class=\"NormalTextRun SCXW125215560 BCX0\">, testing drugs, and advancing tissue engineering.<\/span><\/span><span class=\"EOP SCXW125215560 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><h3>Keywords<\/h3><ul><li>3D tissue barrier model<\/li><li>Cell migration<\/li><li>In vitro model<\/li><li>Tissue engineering<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9b2617 elementor-widget elementor-widget-image\" data-id=\"c9b2617\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/drive.google.com\/file\/d\/1wVh3OTrkIOttf-O4oZguOOIFEj0xNm-a\/view?usp=sharing\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-1024x576.png\" class=\"attachment-large size-large wp-image-3424\" alt=\"\" srcset=\"https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-1024x576.png 1024w, https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-300x169.png 300w, https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-768x432.png 768w, https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-1536x864.png 1536w, https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024-18x10.png 18w, https:\/\/climatesmartagrifood.ca\/wp-content\/uploads\/2026\/01\/Omics-Jalali-et-al-2024.png 1920w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Click to view this visual abstract as a PDF<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e063ebe elementor-widget elementor-widget-text-editor\" data-id=\"e063ebe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3>Research Highlights<\/h3><ul><li>3D tissue barrier models mimic real cell interactions, but building perfusable tissue barriers are difficult<\/li><li>Combining wire molding, collagen self-assembly, and cell migration yields a 3D model compatible with fluid flow<\/li><li>Researchers discovered a simple molding method that forms uniform, high-density barriers with the lowest lab-measured permeability<\/li><li>This new scalable method can help improve drug testing, disease modeling, and tissue engineering<\/li><\/ul><h3>Editorial Reflections<\/h3><p><span data-contrast=\"auto\">In this study, the researchers show how cell migration can be used to create a realistic, fluid 3D barrier model. What makes this especially exciting is that the approach is scalable, opening the door to applications across\u00a0future\u00a0biomedical and pharmaceutical research.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\">Team <strong>Omics4CMeat<\/strong> at McMaster University aims to complement traditional meat production by developing technologies to support cell-cultured meat as an\u00a0additional\u00a0protein source to help reduce GHG emissions. Contributing authors from the team\u00a0are (in alphabetical order):<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559685&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/www.linkedin.com\/in\/aydin-jalali-79219a14b\/?originalSubdomain=ca\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Aydin Jalali<\/span><\/a><span data-contrast=\"none\">\u00a0&#8211; Postdoctoral fellow\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><a href=\"https:\/\/www.linkedin.com\/in\/ravi-selvaganapathy-3a256879\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">P. Ravi Selvaganapathy<\/span><\/a><span data-contrast=\"auto\">\u00a0\u2013\u00a0PI, Omics4CMeat &amp;\u00a0Director,\u00a0Canadian Consortium for Cultivated Meat<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul><p><span data-contrast=\"auto\">Curious about Team <strong>Omics4CMeat<\/strong>\u2019s ongoing work? Visit\u00a0<\/span><a href=\"https:\/\/cccm.mcmaster.ca\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">cccm.mcmaster.ca<\/span><\/a><span data-contrast=\"auto\">\u00a0to learn more.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559685&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><strong><span class=\"TextRun SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239828681 BCX0\">Food for Thought<\/span><span class=\"NormalTextRun SCXW239828681 BCX0\">:<\/span><\/span><\/strong><span class=\"TextRun SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239828681 BCX0\">\u00a0<\/span><span class=\"NormalTextRun SCXW239828681 BCX0\">Read the\u00a0<\/span><\/span><a class=\"Hyperlink SCXW239828681 BCX0\" href=\"https:\/\/doi.org\/10.1039\/D4LC00006D\" target=\"_blank\" rel=\"noopener\"><span class=\"TextRun Underlined SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW239828681 BCX0\" data-ccp-charstyle=\"Hyperlink\">full article here<\/span><\/span><\/a><span class=\"TextRun SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239828681 BCX0\">.\u00a0<\/span><\/span><span class=\"TextRun SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW239828681 BCX0\">Where else in this field, or even beyond it, could this approach make a difference?<\/span><\/span><span class=\"TextRun SCXW239828681 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW239828681 BCX0\">\u00a0What stood out to you or left you curious after reading the study?<\/span><\/span><span class=\"EOP SCXW239828681 BCX0\" data-ccp-props=\"{&quot;335559685&quot;:0}\">\u00a0<\/span><\/p><h3>References<\/h3><p><span class=\"TextRun SCXW141082358 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW141082358 BCX0\">Jalali, S. &amp; Selvaganapathy, P. R. (2024). A self-assembly and cellular\u00a0<\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW141082358 BCX0\">migration based<\/span><span class=\"NormalTextRun SCXW141082358 BCX0\">\u00a0fabrication of high-density 3D tubular constructs of barrier forming membranes.\u00a0<\/span><\/span><span class=\"TextRun SCXW141082358 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW141082358 BCX0\">Lab on a Chip<\/span><\/span><span class=\"TextRun SCXW141082358 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW141082358 BCX0\">, 24(9), 2468\u20132484.\u00a0<\/span><\/span><a class=\"Hyperlink SCXW141082358 BCX0\" href=\"https:\/\/doi.org\/10.1039\/D4LC00006D\" target=\"_blank\" rel=\"noopener\"><span class=\"TextRun Underlined SCXW141082358 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW141082358 BCX0\" data-ccp-charstyle=\"Hyperlink\">https:\/\/doi.org\/10.1039\/D4LC00006D<\/span><\/span><\/a><span class=\"EOP SCXW141082358 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c66fb8 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8c66fb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7bf6182 elementor-widget elementor-widget-text-editor\" data-id=\"7bf6182\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3 aria-level=\"1\"><span data-contrast=\"none\">About the Climate-Smart Agri-Food Network<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:360,&quot;335559739&quot;:80}\">\u00a0<\/span><\/h3><p><span data-contrast=\"none\">Funded by Genome Canada through the\u00a0<\/span><a href=\"https:\/\/genomecanada.ca\/challenge-areas\/climate-smart-agriculture-and-food-systems\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Climate\u2011Smart Agriculture and Food Systems<\/span><\/a><span data-contrast=\"none\">\u00a0portfolio, the Network brings together nine Interdisciplinary Challenge Teams (ICTs) and two hubs \u2014 the\u00a0<\/span><a href=\"https:\/\/climatesmartagrifood.ca\/ag-act-agricultural-genomics-action-centre\/\"><span data-contrast=\"none\">Agricultural Genomics Action Centre (AG\u2011ACt)<\/span><\/a><span data-contrast=\"none\">\u00a0and the\u00a0<\/span><a href=\"https:\/\/climatesmartagrifood.ca\/cs-dcc-climate-smart-data-collaboration-centre\/\"><span data-contrast=\"none\">Climate\u2011Smart Data Collaboration Centre (CS\u2011DCC)<\/span><\/a><span data-contrast=\"none\">\u00a0\u2014 to advance climate\u2011smart agriculture through genomic innovations.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>This study by Team Omics4CMeat focuses on creating a more realistic lab model (&#8220;in vitro model&#8221;) for forming\u00a03D\u00a0tubular tissue barriers that support fluid flow.\u00a0Closely mimicking the behavior of real tissues, this simple yet scalable method holds strong potential for studying diseases, testing drugs, and advancing tissue engineering. Keywords 3D tissue barrier model Cell migration In [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3483,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,8],"tags":[],"class_list":["post-3315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-homepage-news","category-news"],"_links":{"self":[{"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/posts\/3315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/comments?post=3315"}],"version-history":[{"count":9,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/posts\/3315\/revisions"}],"predecessor-version":[{"id":3680,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/posts\/3315\/revisions\/3680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/media\/3483"}],"wp:attachment":[{"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/media?parent=3315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/categories?post=3315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/climatesmartagrifood.ca\/fr\/wp-json\/wp\/v2\/tags?post=3315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}